Apparent RNA bridging between PRC2 and chromatin is an artifact of non-specific chromatin precipitation upon RNA degradation
Summary: Polycomb repressive complex 2 (PRC2) modifies chromatin to maintain repression of genes specific for other cell lineages.In vitro, RNA inhibits PRC2 activity, but the effect of RNA on PRC2 in cells is less clear, with studies concluding that RNA either antagonizes or promotes PRC2 chromatin association.The addition of RNase A to chromatin